This site provides peer-reviewed information about the underlying biology associated with numerous co-occurring medical conditions. The references below are for researchers, clinicians, family members, and those on the autism spectrum.
2023新澳洲幸运10开奖官网直播-开奖结果体彩 Evidence-based Autism Resources
Advances In Research, use the main menu to navigate links to citations describing emerging findings in autism research
BIOMARKERS
Faber S, Zinn GM, Kern Ii JC, Skip Kingston HM. The plasma zinc/serum copper ratio as a biomarker in children with autism spectrum disorders. Biomarkers. 2009 Mar 11:1-10.
James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr. 2004 Dec;80(6):1611-7.
Pastural E, et al. Novel plasma phospholipid biomarkers of autism: Mitochondrial dysfunction as a putative causative mechanism. Prostaglandins Leukot Essent Fatty Acids. 2009 Oct;81(4):253-64.
Yap IK, Angley M, Veselkov KA, Holmes E, Lindon JC, Nicholson JK. Urinary Metabolic Phenotyping Differentiates Children with Autism from Their Unaffected Siblings and Age-Matched Controls. J Proteome Res. 2010 May 13.
澳洲幸运10开奖历史结果-历史开奖记录查询-BIOMEDICAL TREATMENT
Cubała-Kucharska M. The review of most frequently occurring medical disorders related to aetiology of autism and the methods of treatment. Acta Neurobiol Exp. 2010, 70: 141–146.
Goin-Kochel RP, Mackintosh VH, Myers, BJ. Parental reports on the efficacy of treatments and therapies of their children with autism spectrum disorders. Res Autism Spectr Disord. 2009.
Golnik AE, Ireland M. Complementary Alternative Medicine for Children with Autism: A Physician Survey. J Autism Dev Disord. 2009 Mar.
O’Hara NH, Szakacs GM. The recovery of a child with autism spectrum disorder through biomedical interventions. Altern Ther Health Med. 2008 Nov-Dec;14(6):42-4.
Rossignol DA. Novel and emerging treatments for autism spectrum disorders: a systematic review. Ann Clin Psychiatry. 2009 Oct-Dec;21(4):213-36.
DETOXIFICATION
Adams JB, et al. The severity of autism is associated with toxic metal body burden and red blood cell glutathione levels. J Toxicol. 2009;2009:532640.
Adams JB, Romdalvik J, Levine KE, Lin-Wen H. Mercury in first-cut baby hair of children with autism versus typically developing children. Toxicol Environ Chem. 2008, 1–14, iFirst.
Adams JB, et al. Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: Part A–medical results & part B – behavioral results. BMC Clin Pharmacol. 2009 Oct 23;9:16&17.
Aremu DA, Madejczyk MS, Ballatori N. N-acetylcysteine as a potential antidote and biomonitoring agent of methylmercury exposure. Environ Health Perspect. 2008 Jan;116(1):26-31.
Becker KG, Schultz ST. Similarities in features of autism and asthma and a possible link to acetaminophen use. Med Hypotheses. 2010 Jan;74(1):7-11.
Beversdorf DQ, Manning SE, et al. Timing of prenatal stressors and autism. J Autism Dev Disord 2005: 35(4): 471-8.
Blanusa M, et al. Chelators as antidotes of metal toxicity: therapeutic and experimental aspects. Curr Med Chem. 2005;12(23):2771.
Burbacher TM, Shen DD, Liberato N, Grant KS, Cernichiari E, Clarkson T. Comparison of blood and brain mercury levels in infant monkeys exposed to methylmercury or vaccines containing thimerosal. Environ Health Perspect. 2005 Aug;113(8):1015-21.
Cao Y, Chen A, Jones RL, Radcliffe J, Dietrich KN, Caldwell KL, Peddada S, Rogan WJ. Efficacy of succimer chelation of mercury at background exposures in toddlers: a randomized trial. J Pediatr. 2011 Mar;158(3):480-485.e1.
Corsello S, Fulgenzi A, Vietti D, Ferrero ME. The usefulness of chelation therapy for the remission of symptoms caused by previous treatment with mercury-containing pharmaceuticals: a case report. Cases J. 2009 Nov 18;2:199.
Desoto MC, Hitlan RT. Blood Levels of Mercury Are Related to Diagnosis of Autism: A Reanalysis of an Important Data Set. J Child Neurol. 2007 Nov;22(11):1308-1311.
DeSoto MC. Ockham’s Razor and autism: the case for developmental neurotoxins contributing to a disease of neurodevelopment. Neurotoxicology. 2009 May;30(3):331-7.
Dórea JG. Integrating Experimental (In Vitro and In Vivo) Neurotoxicity Studies of Low-dose Thimerosal Relevant to Vaccines. Neurochem Res. 2011 Feb 25.
Emanuele E, et al. Low-grade endotoxemia in patients with severe autism. Neurosci Lett. 2010 Mar 8;471(3):162-5.
Fonnum F, Lock EA. The contributions of excitotoxicity, glutathione depletion and DNA repair in chemically induced injury to neurones: exemplified with toxic effects on cerebellar granule cells. J Neurochem. 2004 Feb;88(3):513-31.
Forman J, et al. A cluster of pediatric metallic mercury exposure cases treated with meso-2,3-dimercaptosuccinic acid (DMSA). Environ Health Perspect. 2000 Jun;108(6):575-7.
Gallagher, Goodman. Hepatitis B triple series vaccine and developmental disability in US children aged 1-9 years. Toxicol Environ Chem. 2008 Sept: 90(5)997-1008.
Goth SR, Chu RA, Gregg JP, Cherednichenko G, Pessah IN. Uncoupling of ATP-mediated calcium signaling and dysregulated interleukin-6 secretion in dendritic cells by nanomolar thimerosal. Environ Health Perspect 2006; 114(7):1083-91.
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Havarinasab S, Hultman P. Organic mercury compounds and autoimmunity. Autoimmunity Rev 2005;4:270-275.
Havarinasab S, Haggqvist B, Bjorn E, Pollard KM, Hultman P. Immunosuppressive and autoimmune effects of thimerosal in mice. Toxicol Appl Pharmacol. 2005 Apr 15;204(2):109-21.
Hewitson L, et al. Delayed acquisition of neonatal reflexes in newborn primates receiving a thimerosal-containing hepatitis B vaccine: influence of gestational age and birth weight. J Toxicol Environ Health A. 2010 Jan;73(19):1298-313.
Holmes AS, et al. Reduced levels of mercury in first baby haircuts of autistic children. Int J Toxicol. 2003 Jul-Aug;22(4):277-85.
Hornig M, et al. Neurotoxic effects of postnatal thimerosal are mouse-strain dependent. Mol Psychiatry. 2004 Sep;9(9):833-45.
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Ip P, Wong V, Ho M, Lee J, Wong W. Mercury exposure in children with autistic spectrum disorder: case-control study. J Child Neurol. 2004 Jun;19(6):431-4.
Kalkbrenner AE, Daniels JL, Chen JC, Poole C, Emch M, Morrissey J. Perinatal exposure to hazardous air pollutants and autism spectrum disorders at age 8. Epidemiology. 2010 Sep;21(5):631-41.
Kern JK, Jones AM. Evidence of toxicity, oxidative stress, and neuronal insult in autism. J Toxicol Environ Health B Crit Rev. 2006 Nov-Dec;9(6):485-99.
Kern JK, et al. Sulfhydryl-reactive metals in autism. J Toxicol Environ Health A. 2007 Apr 15;70(8):715-21.
Kern JK, Geier DA, Adams JB, Geier MR. A biomarker of mercury body-burden correlated with diagnostic domain specific clinical symptoms of autism spectrum disorder. Biometals. 2010 Jun 9.
Lafleur DL, et al. N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder. Psychopharmacology (Berl). 2006 Jan;184(2):254-6.
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Lonsdale D, Shamberfger RJ, Audhya T. Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study. Neuroendocrinol Lett. 2002 Aug;23(4):303-8.Makani S, Gollapudi S, Yel L, Chiplunkar S, Gupta S. Biochemical and molecular basis of thimerosal-induced apoptosis in T cells: a major role of mitochondrial pathway. Genes Immun. 2002 Aug;3(5):270-8.
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Mutter J, Naumann J, et al. Mercury and autism: accelerating evidence? Neuro Endocrinol Lett 2005: 26(5): 439-46.
N-acetylcysteine [No authors listed]. Altern Med Rev. 2000 Oct;5(5):467-71.
Olczak M, et al. Neonatal administration of a vaccine preservative, thimerosal, produces lasting impairment of nociception and apparent activation of opioid system in rats. Brain Res. 2009 Dec 8;1301:143-51.
Pasca SP, Nemes B, Vlase L, Gagyi CE, Dronca E, Miu AC, Dronca M. High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism. Life Sci. 2006 Apr 4;78(19):2244-8.
Pastore A et al. Analysis of glutathione: implication in redox and detoxification. Clin Chim Acta. 2003 Jul 1;333(1):19-39.
Rose S, Melnyk S, et al. The frequency of polymorphisms affecting lead and mercury toxicity among children with autism. Am J Biochem Biotechnol 2008: 4(2): 85-94.
Rush T, Hjelmhaug J, Lobner D. Effects of chelators on mercury, iron, and lead neurotoxicity in cortical culture. Neurotoxicology. 2009 Jan;30(1):47-51.
Schultz, ST. Can autism be triggered by acetaminophen activation of the endocannabinoid system? Acta Neurobiol Exp 2010, 70: 227–231.
Shannon M, Graef JW. Lead intoxication in children with pervasive developmental disorders. J Toxicol Clin Toxicol. 1996;34(2):177-81.
Stamova B, et al. Correlations Between Gene Expression and Mercury Levels in Blood of Boys With and Without Autism. Neurotox Res. 2009 Nov 24.
Stangle DE, et al. Succimer chelation improves learning, attention and arousal regulation in lead-exposed rats but produces lasting cognitive impairment in the absence of lead exposure. Environ Health Perspect. 30 October 2006.
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Tian Y, et al. Correlations of Gene Expression with Blood Lead Levels in Children with Autism Compared to Typically Developing Controls. Neurotox Res. 2009 Nov 17.
Waly M, et al. Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal. Mol Psychiatry. 2004 Apr;9(4):358-7
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Yousef S, Adem A, Zoubeidi T, Kosanovic M, Mabrouk AA, Eapen V. Attention Deficit Hyperactivity Disorder and Environmental Toxic Metal Exposure in the United Arab Emirates. J Trop Pediatr. 2011 Feb 6.
Zoroglu SS, et al. Pathophysiological role of nitric oxide and adrenomedullin in autism. Cell Biochem Funct. 2003 Mar;21(1):55-60.
2023澳洲幸运10开奖历史记录-开奖历史查询-官方最新开奖-开奖结果体彩， ENVIRONMENT
Bouchard MF, Bellinger DC, Wright RO, Weisskopf MG. Attention-deficit/hyperactivity disorder and urinary metabolites of organophosphate pesticides. Pediatrics. 2010 Jun;125(6):e1270-7.
Curtis JT, Hood AN, Chen Y, Cobb GP, Wallace DR. Chronic metals ingestion by prairie voles produces sex-specific deficits in social behavior: an animal model of autism. Behav Brain Res. 2010 Nov 12;213(1):42-9.
DeSoto MC, Hitlan RT. Sorting out the spinning of autism: heavy metals and the question of incidence. Acta Neurobiol Exp 2010, 70: 165.
Deth R, et al. How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis. Neurotoxicology 2008: 29(1): 190-201.
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Hewitson L, Lopresti B, Stott C, Mason NS, Tomko J. Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: A pilot study. Acta Neurobiol Exp 2010, 70: 147–164.
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澳洲10官方开奖视频记录-澳洲幸运十开奖记录查询 GASTROINTESTINAL SYSTEM
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METABOLISM
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OXIDATIVE STRESS
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PREVALENCE
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